Isaiah 1:5 NIV
5 Why should you be beaten anymore? Why do you persist in rebellion? Your whole head is injured, your whole heart afflicted.
Isaiah 1:5 JUB
5 Why should I chastise you anymore? Ye will revolt more and more; every head is sick, and every heart faint.
As we enter into Isaiah, the first occurrence of the word heart occurs in chapter one as above, the next not until chapter six. Chapter one introduces a vision given to Isaiah concerning Judah and Jerusalem and it was not one they wanted for they were wicked and rebellious.
How rebellious and wicked were they? The NIV points to the whole head being injured and the whole heart being afflicted meaning the whole of the people. The JUB points to rebelliousness and wickedness as a poisonous epidemic that has spread everywhere even to the head (rational thought) and the heart (center of emotion).
The next two verses show a picture of the disease as both individual and national and the picture is not pretty
6 From the sole of your foot to the top of your head there is no soundness—only wounds and welts and open sores, not cleansed or bandaged or soothed with olive oil.
7 Your country is desolate, your cities burned with fire; your fields are being stripped by foreigners right before you, laid waste as when overthrown by strangers.
In these passages Judah and Jerusalem are receiving judgments as punishment for their crimes. The effect of the punishment was to see them persist in rebellion because their hearts are so corrupted.
Where the heart is right with God, the tendency of affliction is to humble it, and lead it more and more to God. Where it is evil, the tendency is to make the sinner more obstinate and rebellious. This effect of punishment is seen everywhere. Sinners revolt more and more. They become sullen, and malignant, and fretful; they plunge into vice to seek temporary relief, and thus they become more and more alienated from God. Barnes’ Notes on the Bible
I can look to my own past and see the truth in the above quote until I finally turned to God. You can probably look at people in your own lives who have yet to reach rock bottom and so still rebel and rail against God, not understanding just how great and deep is His love for them. So He waits for the rebellion to end as eventually it must either in death or in turning to God and His Son Jesus. The truly lost are those who revolt even into death, but the joy of the saved comes anytime a person turns to Jesus and accepts Him as Lord and Savior. Or as Jesus said,
“In the same way, I tell you, there is rejoicing in the presence of the angels of God over one sinner who repents.” Luke 15:10